How many immunotherapy trials in breast cancer translate into positive phase III trials?
Many trials fail to produce results and to translate into
CDK4/6 inhibition with palbociclib, in combination with fulvestrant, trastuzumab and pertuzumab, triggers sustained senescence: new data from a Michelangelo Foundation study.
Atezolizumab added to nab-paclitaxel and carboplatin as neoadjuvant therapy did not increase the rate of pathological complete remission, mostly influenced by PD-L1 expression.
NA-PHER2 trial, coordinated by Michelangelo Foundation, shows their efficacy as neoadjuvant therapy, with a relevant effect on Ki67
Lead by Michelangelo Foundation and Gianni Bonadonna Foundation’s experts, a review published on Nature Reviews – Clinical Oncology highlights the state of the art therapy in triple-negative breast cancer
Many trials fail to produce results and to translate into
Postdiagnosis/pretreatment exercise may lower risk of recurrence of breast cancer,
With a longer follow-up of 41 months, trastuzumab-deruxtecan continues to
A retrospective analysis of patients treated with locoregional therapy but
A PET-based, pathological complete response-adapted strategy leads to excellent 3-year
In the phase II aceIERA trial, giredestrant was well tolerated
Addition of palbociclib to fulvestrant did not improve progression-free survival,
With the passing of Pinuccia Valagussa, co-founder of the Michelangelo
A new review from Italian researchers summarizes evidence of efficacy
The final analysis of phase III PEONY trial confirms a
Results from the NATALEE trial show disease-free survival benefits with
INAVO120 trial primary analysis shows benefits with inavosilib added to
Higher pathologic complete response rate with atezolizumab added to anthracycline
A phase I/II trial shows that this HER3-targeted antibody-drug conjugate
An individual patient data metanalysis suggests that oral SERDs improve
A study from Michelangelo Foundation researchers in collaboration with San
No Event-free survival improvement by addition of atezolizumab to neoadjuvant
The phase 3 trial TROPiCS-02 shows that the antibody-drug conjugate
The SUMMIT study shows that the combination of neratinib, fulvestrant
A canadian study shows that screening programs for women in
A new study by the Michelangelo Foundation, in collaboration with
The phase 2 DAISY trial suggests that HER2 expression is
Oncotype DX helps to decrease discordancy in adjuvant chemotherapy recommendations
Among selected patients with previous hormone receptor–positive early breast cancer,
PROTAC, a new MDM2-targeted degrader, kills p53-inactivated triple negative breast
Compared with physician’s choice treatment, trastuzumab deruxtecan shows a favorable
Anthracycline plus taxane regimens are among the most efficacious at
The GELATO trial shows the feasibility of trials specifically designed
Patients with HER2-positive early breast cancer who achieve a pathologic
ctDNA and residual cancer burden after neoadjuvant systemic therapy are
The effects of omission of radiotherapy after surgery on local
Enrollment of patients with HER2+ metastatic breast cancer and PIK3CA
Olaparib significantly prolonged progression-free survival compared to chemotherapy, particularly in
This multicentric machine learning model improves performance of local models
Foundation’s experts and data in key educational sessions to share
Lead by Michelangelo Foundation and Gianni Bonadonna Foundation’s experts, a
NA-PHER2 trial, coordinated by Michelangelo Foundation, shows their efficacy as
Atezolizumab added to nab-paclitaxel and carboplatin as neoadjuvant therapy did
CDK4/6 inhibition with palbociclib, in combination with fulvestrant, trastuzumab and
CDK4/6 inhibition with palbociclib, in combination with fulvestrant, trastuzumab and
Atezolizumab added to nab-paclitaxel and carboplatin as neoadjuvant therapy did
NA-PHER2 trial, coordinated by Michelangelo Foundation, shows their efficacy as
Lead by Michelangelo Foundation and Gianni Bonadonna Foundation’s experts, a
Foundation’s experts and data in key educational sessions to share
This multicentric machine learning model improves performance of local models